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You will have to be a bit more specific with your requirements. Is it a pure office machine? Are you gaming? What's your budget? Do you plan on buying the GPU used since you mentioned the GTX 1080 which is hard to come by new these days?
Edit: ok, so a work station. What programs specifically? Do you even need a powerful GPU for anything you are doing?
You will have to be a bit more specific with your requirements. Is it a pure office machine? Are you gaming? What's your budget? Do you plan on buying the GPU used since you mentioned the GTX 1080 which is hard to come by new these days?
Edit: ok, so a work station. What programs specifically? Do you even need a powerful GPU for anything you are doing?
Then practically any GPU will do the job as long as it has enough video outputs. A faster card will gain you nothing. Buying a card like a 1080 is a waste of money and energy (and space if your case isn't that big). The cheapest modern card with 4 ports would be something like an AMD RX 570. They will mostly have Displayport outputs, but a cheap adapter will solve that if you require more HDMI outputs.
Which CPU is used by the machine? Chances are you might not even need a separate GPU but may use the CPU’s built-in graphics (iGPU). Intel’s seventh generation CPUs offer connecting up to three monitors. While some heavy-duty workstation/server CPUs omit graphics completely, some still offer it. Then it depends on the outputs of the mainboard suiting the inputs of your monitors. So, which CPU, which board, which monitors?
Just buy your card by the needed Monitor-Connectors.
Everey GPU since AMD HD5000 and Nvidia Kepler is capable of doing this, if the connections are build in.
Since you need four Displays simultaneously you can resarch if two small Cards (with the right connectors for your displays) will be cheaper than a bigger one with all the right connectors.
And you should keep in mind that a large scale of AMD-Cards need a active DP-Adapter to utilize more than two NON-DP Displays.